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Article

The Apicomplexa-specific glucosamine-6-phosphate N-acetyltransferase gene family encodes a key enzyme for glycoconjugate synthesis with potential as therapeutic target.

Scientific reports - 5 Mar 2018

Cova Marta, López-Gutiérrez Borja, Artigas-Jerónimo Sara, González-Díaz Aida, Bandini Giulia, Maere Steven, Carretero-Paulet Lorenzo, Izquierdo Luis

Abstract excerpt

Apicomplexa form a phylum of obligate parasitic protozoa of great clinical and veterinary importance. These parasites synthesize glycoconjugates for their survival and infectivity, but the enzymatic steps required to generate the glycosylation precursors are not completely characterized. In particular, glucosamine-phosphate N-acetyltransferase (GNA1) activity, needed to produce the essential...

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Identifiers

PMID: 29507322
DOI: 10.1038/s41598-018-22441-3
PMCID: PMC5838249

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