Article
Ablation of N-acetylglucosaminyltransferases in Caenorhabditis induces expression of unusual intersected and bisected N-glycans.
Biochimica et biophysica acta. General subjects - 1 Oct 2018
Yan Shi, Wang Huijie, Schachter Harry, Jin Chunsheng, Wilson Iain B H, Paschinger Katharina
Abstract excerpt
The modification in the Golgi of N-glycans by N-acetylglucosaminyltransferase I (GlcNAc-TI, MGAT1) can be considered to be a hallmark of multicellular eukaryotes as it is found in all metazoans and plants, but rarely in unicellular organisms. The enzyme is key for the normal processing of N-glycans to either complex or paucimannosidic forms, both of which are found in the model nematode Caenorhabditis elegans....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.