Article
Comparative molecular dynamics simulation of Hepatitis C Virus NS3/4A protease (Genotypes 1b, 3a and 4b) predicts conformational instability of the catalytic triad in drug resistant strains.
PloS one - 1 Jan 2014
Kramer Mitchell, Halleran Daniel, Rahman Moazur, Iqbal Mazhar, Anwar Muhammad Ikram, Anwar Muhmad Ikram, Sabet Salwa, Ackad Edward, Yousef Mohammad S, Yousef Mohammad
Abstract excerpt
The protease domain of the Hepatitis C Virus (HCV) nonstructural protein 3 (NS3) has been targeted for inhibition by several direct-acting antiviral drugs. This approach has had marked success to treat infections caused by HCV genotype 1 predominant in the USA, Europe, and Japan. However, genotypes 3 and 4, dominant in developing countries, are resistant to a number of these drugs and little progress has been...
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