Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modelling of Hepatitis E virus RNA-dependent RNA polymerase genotype 3 from a chronic patient and in silico interaction analysis by molecular docking with Ribavirin.

Journal of biomolecular structure & dynamics - 1 Feb 2023

Cancela Florencia, Rendon-Marin Santiago, Quintero-Gil Carolina, Houston Douglas R, Gumbis Gediminas, Panzera Yanina, Pérez Ruben, Arbiza Juan, Mirazo Santiago

Abstract excerpt

Hepatitis E Virus (HEV) infection is an emergent zoonotic disease, where chronic hepatitis E associated to solid organ transplant (SOT) recipients, related to genotype 3, is the clinical manifestation of major concern. In this setting, ribavirin (RBV) treatment is the only available therapy, though drug-resistant variants could emerge leading to a therapeutic failure. Crystallographic structures have not been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis E

Share to Hepatitis E virus

Share to Molecular Docking Simulation

Share to Ribavirin

Share to RNA-Dependent RNA Polymerase

Source

Identifiers

PMID: 34861797
DOI: 10.1080/07391102.2021.2011416

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modelling of Hepatitis E virus RNA-dependent RNA polymerase genotype 3 from a chronic patient and in silico interaction analysis by molecular docking with Ribavirin.PMID 34861797Read ↗

A holistic evolutionary and structural study of flaviviridae provides insights into the function and inhibition of HCV helicaseSemantic proximity Read ↗

Molecular models of NS3 protease variants of the Hepatitis C virus.Semantic proximity Read ↗

Applications of computer-aided approaches in the development of hepatitis C antiviral agentsSemantic proximity Read ↗

Using the Hepatitis C Virus RNA-Dependent RNA Polymerase as a Model to Understand Viral Polymerase Structure, Function and DynamicsSemantic proximity Read ↗

The euHCVdb suite of in silico tools for investigating the structural impact of mutations in hepatitis C virus proteins.Semantic proximity Read ↗

The Role of the RNA-RNA Interactome in the Hepatitis C Virus Life CycleSemantic proximity Read ↗

Probing the "fingers" domain binding pocket of Hepatitis C virus NS5B RdRp and D559G resistance mutation via molecular docking, molecular dynamics simulation and binding free energy calculations.Semantic proximity Read ↗

SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspectiveSemantic proximity Read ↗

Hepatitis E genotype 3 genome: A comprehensive analysis of entropy, motif conservation, relevant mutations, and clade-associated polymorphismsSemantic proximity Read ↗

Structure Prediction and Analysis of Hepatitis E Virus Non-Structural Proteins from the Replication and Transcription Machinery by AlphaFold2Semantic proximity Read ↗

Identification of potential inhibitors for HCV NS3 genotype 4a by combining protein-ligand interaction fingerprint, 3D pharmacophore, docking, and dynamic simulation.Semantic proximity Read ↗

Flexibility and intrinsic disorder are conserved features of hepatitis C virus E2 glycoproteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.