Article
TNF-alpha-, TNF-beta-, IL-6-, and IL-10-promoter polymorphisms in patients with chronic obstructive pulmonary disease.
Tissue antigens - 1 Jan 2005
Seifart C, Dempfle A, Plagens A, Seifart U, Clostermann U, Müller B, Vogelmeier C, von Wichert P
Abstract excerpt
Chronic obstructive pulmonary disease (COPD) is a major health problem. The disease is driven by abnormal inflammatory reactions in response to inhaled particles and fumes. Therefore, inflammatory mediators are postulated to be of distinct importance. In the present case-control study, we investigated interleukin (IL)-promoter polymorphisms known to correlate with altered transcription levels of their gene...
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