Article
TNF-308 gene polymorphism is associated with COPD risk among Asians: meta-analysis of data for 6,118 subjects.
Molecular biology reports - 1 Jan 2011
Zhan Ping, Wang Jing, Wei Shu-Zhen, Qian Qian, Qiu Li-Xin, Yu Li-Ke, Song Yong
Abstract excerpt
Chronic obstructive pulmonary disease (COPD) is a complex polygenic disease in which gene-environment interactions play a critical role in disease onset and progression. The gene encoding tumor necrosis factor (TNF) is one of several candidate loci for the pathogenesis of COPD and is highly polymorphic. A number of studies have investigated the association between the TNF-308 polymorphisms and COPD risk in...
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