Article
CYP1A2 in a smoking and a non-smoking population; correlation of urinary and salivary phenotypic ratios.
Drug metabolism and drug interactions - 1 Jan 2004
Woolridge Helen, Williams John, Cronin Anna, Evans Nicola, Steventon Glyn B
Abstract excerpt
The use of caffeine as a probe for CYP1A2 phenotyping has been extensively investigated over the last 25 years. Numerous metabolic ratios have been employed and various biological fluids analysed for caffeine and its metabolites. These investigations have used non-smoking, smoking and numerous disease populations to investigate the role of CYP1A2 in possible disease aetiology and for induction and inhibition...
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