Caffeine as a probe for CYP1A2 activity: potential influence of renal factors on urinary phenotypic trait measurements.

Article

Caffeine as a probe for CYP1A2 activity: potential influence of renal factors on urinary phenotypic trait measurements.

Pharmacogenetics - 1 Jun 1994

Tang B K, Zhou Y, Kadar D, Kalow W

Abstract excerpt

Two established caffeine-based urinary methods for measuring CYP1A2 activity were compared with each other, and also with the systemic clearance of caffeine which served as a standard of reference for such activity. Following a standardized dose, caffeine (137X) and its metabolites were measured...

Topics

Adult
Biotransformation
Caffeine
Cytochrome P-450 CYP1A2
Cytochrome P-450 Enzyme System
Female
Humans
Kidney
Male
Metabolic Clearance Rate
Molecular Probes
Oxidoreductases
Phenotype
Reference Values

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