Article
Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism.
Diabetologia - 1 Dec 2004
Liew C F, Groves C J, Wiltshire S, Zeggini E, Frayling T M, Owen K R, Walker M, Hitman G A, Levy J C, O'rahilly S, Hattersley A T, Johnston D G, McCarthy M I
Abstract excerpt
AIMS/HYPOTHESIS: Stearoyl-CoA desaturase (SCD) is emerging as a key regulator of lipid and carbohydrate metabolism. Scd-null mice display a beneficial metabolic phenotype characterised by resistance to obesity, diabetes and hyperlipidaemia. The human homologue, SCD, maps to a region of chromosome 10 linked to type 2 diabetes, and SCD activity correlates with insulin sensitivity. Given this strong positional and...
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