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Article

Matrix metalloproteinase 1 gene polymorphism as a prognostic predictor of invasive cervical cancer.

Gynecologic oncology - 1 Feb 2005

Lai Hung-Cheng, Chu Chi-Ming, Lin Ya-Wen, Chang Cheng-Chang, Nieh Shin, Yu Mu-Hsien, Chu Tang-Yuan

Abstract excerpt

OBJECTIVES: Whereas human papillomavirus (HPV) infection is the major determinant of cervical carcinogenesis, host genetic factors may confer individual susceptibility and prognosis. Matrix metalloproteinase 1 (MMP-1) is an important modulator of carcinogenesis. A guanine insertion (2G) polymorphism at nucleotide -1607 of the MMP-1 gene promoter creates an Ets-1-binding site, which increases transcription...

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Identifiers

PMID: 15661214
DOI: 10.1016/j.ygyno.2004.09.065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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