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Article

Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, Podocin, and CD2 associated protein in cultured human podocytes.

Journal of the American Society of Nephrology : JASN - 1 Mar 2005

Coward Richard J M, Foster Rebecca R, Patton David, Ni Lan, Lennon Rachel, Bates David O, Harper Steven J, Mathieson Peter W, Saleem Moin A

Abstract excerpt

Podocytes are critical in maintaining the filtration barrier of the glomerulus and are dependent on the slit diaphragm (SD) proteins nephrin, podocin, and CD2-associated protein (CD2AP) to function optimally. The effects of normal human plasma and nephrotic plasma on podocytes were tested, focusing particularly on the SD complex. With the use of a conditionally immortalized human podocyte cell line, it first was...

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Identifiers

PMID: 15659563
DOI: 10.1681/ASN.2004030172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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