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Article

Genetic kidney diseases disclose the pathogenesis of proteinuria.

Annals of medicine - 1 Nov 2001

Jalanko H, Patrakka J, Tryggvason K, Holmberg C

Abstract excerpt

The sieving of plasma components occurs in the kidney through the glomerular capillary wall. This filter is composed of three layers: endothelium, glomerular basement membrane (GBM), and podocyte foot processes connected by slit diaphragms. Defects in this barrier lead to proteinuria and nephrotic syndrome. Previously, defective GBM was regarded to be responsible for proteinuria. However, recent work on genetic...

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Source

Identifiers

PMID: 11730159
DOI: 10.3109/07853890108995962

Genes

NPHS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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