Article
Prognostic implications of hMLH1 and p53 immunohistochemical status in right-sided colon cancer.
Diseases of the colon and rectum - 1 Dec 2004
Smyth Edward F, Sharma Abhiram, Sivarajasingham Nala, Hartley John, Monson John R T, Cawkwell Lynn
Abstract excerpt
PURPOSE: Extensive research into the molecular biology of colorectal cancer has identified a plethora of molecular markers reputed to provide independent prognostic information. p53 mutational status has been associated with both improved and reduced survival; however, tumors expressing a particular phenotype associated with defective mismatch repair consistently do better. This study was designed to examine...
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