Article
Microsatellite instability and p53 mutations in sporadic right and left colon carcinoma: different clinical and molecular implications.
Cancer - 1 Sept 1998
Lleonart M E, García-Foncillas J, Sánchez-Prieto R, Martín P, Moreno A, Salas C, Ramón y Cajal S
Abstract excerpt
BACKGROUND: Left and right colon carcinomas can display different clinical, pathologic, and genetic characteristics. The purpose of this study was to characterize multiple molecular genetic alterations in sporadic colon carcinoma and to correlate them with the location of the tumors and with lymp...
Topics
- Adaptor Proteins, Signal Transducing
- Carrier Proteins
- Colonic Neoplasms
- DNA Repair
- DNA-Binding Proteins
- Exons
- Genes, p53
- Humans
- Lymphatic Metastasis
- Microsatellite Repeats
- MutL Protein Homolog 1
- MutS Homolog 2 Protein
- Mutation
- Neoplasm Proteins
- Nuclear Proteins
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Proto-Oncogene Proteins