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Article

A role for ADP ribosylation factor in the control of cargo uptake during COPI-coated vesicle biogenesis.

FEBS letters - 3 Dec 1999

Malsam J, Gommel D, Wieland F T, Nickel W

Abstract excerpt

ARF-mediated hydrolysis of GTP has been demonstrated to regulate coat disassembly of Golgi-derived COPI transport vesicles (Tanigawa, G., Orci, L., Amherdt, M., Ravazzola, M., Helms, J.B. and Rothman, J.E. (1993) J. Cell Biol. 123, 1365-1371). In addition, a requirement for GTP hydrolysis at an early stage of COPI vesicle biogenesis has been established since cargo uptake is impaired in the presence of GTPgammaS...

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PMID: 10622709
DOI: 10.1016/s0014-5793(99)01543-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A role for ADP ribosylation factor in the control of cargo uptake during COPI-coated vesicle biogenesis.PMID 10622709Read ↗

ARFGAP1 plays a central role in coupling COPI cargo sorting with vesicle formation.Semantic proximity Read ↗

COPI vesicles accumulating in the presence of a GTP restricted arf1 mutant are depleted of anterograde and retrograde cargo.Semantic proximity Read ↗

ARF is required for maintenance of yeast Golgi and endosome structure and function.Semantic proximity Read ↗

Scission of COPI and COPII vesicles is independent of GTP hydrolysis.Semantic proximity Read ↗

ADP-ribosylation factor is functionally and physically associated with the Golgi complex.Semantic proximity Read ↗

Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors.Semantic proximity Read ↗

A role for BARS at the fission step of COPI vesicle formation from Golgi membrane.Semantic proximity Read ↗

ADP-Ribosylation factor 1 (ARF1) regulates recruitment of the AP-3 adaptor complex to membranes.Semantic proximity Read ↗

The ArfGAP Glo3 is required for the generation of COPI vesicles.Semantic proximity Read ↗

Mutations in a highly conserved region of the Arf1p activator GEA2 block anterograde Golgi transport but not COPI recruitment to membranes.Semantic proximity Read ↗

The ARF exchange factors Gea1p and Gea2p regulate Golgi structure and function in yeast.Semantic proximity Read ↗

Functional diversification of closely related ARF-GEFs in protein secretion and recycling.Semantic proximity Read ↗

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