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Article

Coupling of caspase-9 to Apaf1 in response to loss of pRb or cytotoxic drugs is cell-type-specific.

The EMBO journal - 28 Jan 2004

Ho Andrew T, Li Qin H, Hakem Razqallah, Mak Tak W, Zacksenhaus Eldad

Abstract excerpt

Inactivation of the tumor suppressor Rb in the mouse induces cell death, which depends entirely (in lens, CNS) and only partly (PNS, skeletal muscles) on Apaf1/Ced4, an apoptosomal factor thought to be required for processing procaspase-9 following mitochondrial permeabilization. Here, we report...

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Identifiers

PMID: 14713951
DOI: 10.1038/sj.emboj.7600039
PMCID: PMC1271749

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14713951-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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