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D120 and K152 within the PH Domain of T Cell Adapter SKAP55 Regulate Plasma Membrane Targeting of SKAP55 and LFA-1 Affinity Modulation in Human T Lymphocytes.

Molecular and cellular biology - 1 Apr 2017

Witte Amelie, Meineke Bernhard, Sticht Jana, Philipsen Lars, Kuropka Benno, Müller Andreas J, Freund Christian, Schraven Burkhart, Kliche Stefanie

Abstract excerpt

The β2-integrin lymphocyte function-associated antigen 1 (LFA-1) is needed for the T cell receptor (TCR)-induced activation of LFA-1 to promote T cell adhesion and interaction with antigen-presenting cells (APCs). LFA-1-mediated cell-cell interactions are critical for proper T cell differentiation and proliferation. The Src kinase-associated phosphoprotein of 55 kDa (SKAP55) is a key regulator of TCR-mediated...

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PMID: 28052935
DOI: 10.1128/MCB.00509-16
PMCID: PMC5359422

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