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Article

Decreased selective uptake of high density lipoprotein cholesteryl esters in apolipoprotein E knock-out mice.

Proceedings of the National Academy of Sciences of the United States of America - 12 Oct 1999

Arai T, Rinninger F, Varban L, Fairchild-Huntress V, Liang C P, Chen W, Seo T, Deckelbaum R, Huszar D, Tall A R

Abstract excerpt

Scavenger receptor BI (SR-BI) mediates the selective uptake of high density lipoprotein (HDL) cholesteryl esters (CE) by cells, i.e., the uptake of CE without degradation of HDL protein. Mice with attenuated expression of SR-BI, because of targeted gene mutation (SR-BIatt mice), have increased plasma HDL levels as a result of decreased selective uptake in the liver. To further evaluate the role of SR-BI in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10518574
DOI: 10.1073/pnas.96.21.12050
PMCID: PMC18410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Decreased selective uptake of high density lipoprotein cholesteryl esters in apolipoprotein E knock-out mice.PMID 10518574Read ↗

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A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism.Semantic proximity Read ↗

Increased apolipoprotein M induced by lack of scavenger receptor BI is not activated via HDL-mediated cholesterol uptake in hepatocytes.Semantic proximity Read ↗

Knockdown expression and hepatic deficiency reveal an atheroprotective role for SR-BI in liver and peripheral tissues.Semantic proximity Read ↗

Influence of the HDL Receptor SR-BI on Lipoprotein Metabolism and AtherosclerosisSemantic proximity Read ↗

SR-BI mediates cholesterol efflux via its interactions with lipid-bound ApoE. Structural mutations in SR-BI diminish cholesterol efflux.Semantic proximity Read ↗

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Functional genomics of the human high-density lipoprotein receptor scavenger receptor BI: an old dog with new tricks.Semantic proximity Read ↗

Genetic studies in mice and humans reveal new physiological roles for the high-density lipoprotein receptor scavenger receptor class B type I.Semantic proximity Read ↗

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Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.Semantic proximity Read ↗

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