Article
Impaired ventilatory acclimatization to hypoxia in mice lacking the immediate early gene fos B.
Respiratory physiology & neurobiology - 15 Jan 2005
Malik Mohammad T, Peng Ying-Jie, Kline David D, Adhikary Gautam, Prabhakar Nanduri R
Abstract excerpt
Earlier studies on cell culture models suggested that immediate early genes (IEGs) play an important role in cellular adaptations to hypoxia. Whether IEGs are also necessary for hypoxic adaptations in intact animals is not known. In the present study we examined the potential importance of fos B, an IEG in ventilatory acclimatization to hypoxia. Experiments were performed on wild type and mutant mice lacking the...
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