Article
Reduced hypoxic ventilatory response in newborn mice knocked-out for the progesterone receptor.
Experimental physiology - 1 Nov 2014
Potvin Catherine, Rossignol Orlane, Uppari NagaPraveena, Dallongeville Arnaud, Bairam Aida, Joseph Vincent
Abstract excerpt
Recent studies showed that progesterone stimulates the hypoxic ventilatory response and may reduce apnoea frequency in newborn rats, but so far we still do not know by what mechanisms and whether endogenous progesterone might contribute to respiratory control in neonates. We therefore determined the role of the nuclear progesterone receptor (PR; member of the steroid receptor superfamily) by using wild-type (WT)...
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