Article
Differences in sleep-induced hypoxia between A/J and DBA/2J mouse strains.
American journal of respiratory and critical care medicine - 15 Dec 2003
Rubin Arnon E, Polotsky Vsevolod Y, Balbir Alexander, Krishnan Jerry A, Schwartz Alan R, Smith Philip L, Fitzgerald Robert S, Tankersley Clarke G, Shirahata Machiko, O'Donnell Christopher P
Abstract excerpt
In obstructive sleep apnea, hypoxic ventilatory sensitivity may affect the degree of hypoxic stress and sleep disruption that occurs in response to upper airway obstruction. We induced (1) sleep-induced hypoxia (SIH) or (2) sleep fragmentation (SF) without hypoxia for 5 days (12-hour light/dark cycle) in two inbred mouse strains with low (A/J) and high (DBA/2J) hypoxic ventilatory sensitivities. During SIH, the...
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