Article
Impaired ventilatory responses to hypoxia and hypercapnia in mutant mice deficient in endothelin-1.
The American journal of physiology - 1 Jun 1996
Kuwaki T, Cao W H, Kurihara Y, Kurihara H, Ling G Y, Onodera M, Ju K H, Yazaki Y, Kumada M
Abstract excerpt
We studied respiratory functions in mutant mice deficient in endothelin-1 (ET-1) generated by gene targeting. In conscious adult mice heterozygous for ET-1 gene mutation (ET+/- heterozygous mice), arterial PO2 was significantly lower, PCO2 tended to be higher, and pH tended to be lower than in wild-type littermates. When these conscious mice breathed room air, respiratory minute volume and rate, determined by...
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