Membrane stabilization by intimate contact between cells reduces their Mg2+ activity and suppresses the neoplastic phenotype.

Abstract excerpt

The mechanism of normalizing transformed cells by contact with normal cells is considered in relation to the mechanism of stimulating the growth of normal contact-inhibited cells. Stimulation is based on perturbation of the plasma membrane throughout the G1 period by growth factors. A primary effect of the membrane perturbation is a long-sustained increase of intracellular free Mg(2+) which increases the...

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