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Article

Environmental induction of tumor phenotype in a putative Kaposi sarcoma progenitor cell.

Lymphology - 1 Mar 1994

Mallery S R, Lantry L E, Hegtvedt A, Lazo A, Titterington L C, Hout B L, Brierley G P, Stephens R E

Abstract excerpt

Many features of AIDS-related Kaposi sarcoma (AIDS-KS), e.g., multifocal lesional presentation at sites perfused by the microvasculature, suggest that AIDS-KS is initially a hyperplasia that subsequently progresses to a neoplasia. We propose that the unique AIDS environment, which contains high levels of circulating factors such as viral cytokines, is key in initiating the KS lesion. Further, we maintain that due...

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PMID: 8207969

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