Article
Construction of a rhamnose mutation in Bacillus anthracis affects adherence to macrophages but not virulence in guinea pigs.
Microbial pathogenesis - 1 Jan 2005
Bozue Joel A, Parthasarathy Narayanan, Phillips Lawrence R, Cote Christopher K, Fellows Patricia F, Mendelson Itai, Shafferman Avigdor, Friedlander Arthur M
Abstract excerpt
Carbohydrate analyses of whole-spore extracts have confirmed the presence of rhamnose in the spore of the fully virulent Ames strain of Bacillus anthracis. A gene cluster containing loci with high homology to the rhamnose biosynthetic genes, rmlACBD, was identified within the B. anthracis chromosome. The first gene of this cluster, rmlA, was inactivated by forming a merodiploid cointegrate using an internal...
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