The integrin Mac-1 (CR3) mediates internalization and directs <i>Bacillus anthracis</i> spores into professional phagocytes

Abstract excerpt

Anthrax, a disease caused by Bacillus anthracis, affects animals and humans. Because the inert spore is the infectious form of the organism that first contacts the potential host, the interaction between the host and spore exosporium is vital to the initiation of disease. Here, we demonstrate that the integrin Mac-1 is essential for the recognition of the major exosporium protein BclA by phagocytic cells....

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