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Isofurans: Novel Products of Lipid Peroxidation that Define the Occurrence of Oxidant Injury in Settings of Elevated Oxygen Tension

23 Dec 2004

Abstract excerpt

We recently reported the discovery of isofurans, novel products of free radical-induced peroxidation of arachidonic acid that exhibit favored formation with increasing oxygen concentrations. In this review, the biochemistry of isofuran formation is compared with that of isoprostanes, with an emphasis on the mechanistic basis for the favored formation of isofurans at elevated oxygen tensions. In addition, the...

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PMID: 15650408
DOI: 10.1089/ars.2005.7.202

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