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Article

Isolevuglandin Adducts in Disease

4 Jan 2015

Abstract excerpt

SIGNIFICANCE: A diverse family of lipid-derived levulinaldehydes, isolevuglandins (isoLGs), is produced by rearrangement of endoperoxide intermediates generated through both cyclooxygenase (COX) and free radical-induced cyclooxygenation of polyunsaturated fatty acids and their phospholipid esters. The formation and reactions of isoLGs with other biomolecules has been linked to alcoholic liver disease, Alzheimer's...

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PMID: 25557218
DOI: 10.1089/ars.2014.6154

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