Article
Elevated cerebrospinal fluid F2-isoprostane levels indicating oxidative stress in healthy siblings of multiple sclerosis patients.
Neuroscience letters - 13 Mar 2007
Mattsson Niklas, Haghighi Sara, Andersen Oluf, Yao Yuemang, Rosengren Lars, Blennow Kaj, Praticò Domenico, Zetterberg Henrik
Abstract excerpt
Lipid peroxidation has been implicated in the pathogenesis of multiple sclerosis (MS). Isoprostanes, isomers of prostaglandins, are produced by free radical-mediated peroxidation of fatty acids in vivo and can be quantified in biological fluids. This study examines the levels of cerebrospinal fluid (CSF) F2-isoprostanes (F2-iPs) in MS patients (n=46), their healthy siblings (n=46) and unrelated controls (n=50)....
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