Article
Three-dimensional model and molecular mechanism of Mycobacterium tuberculosis catalase-peroxidase (KatG) and isoniazid-resistant KatG mutants.
Microbial drug resistance (Larchmont, N.Y.) - 1 Jan 2004
Mo L, Zhang W, Wang J, Weng X H, Chen S, Shao L Y, Pang M Y, Chen Z W
Abstract excerpt
Mycobacterium tuberculosis KatG enzyme functions both as catalase for removing hydrogen peroxide (H(2)O(2)) and as peroxidase for oxidating isoniazid (INH) to active form of anti-tuberculosis drug. Although mutations in M. tuberculosis KatG confer INH resistance in tuberculous patients, structural bases for INH-resistant mutations in the KatG gene remains poorly understood. Here, three M. tuberculosis KatG...
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