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Article

Crystal structure of Mycobacterium tuberculosis catalase-peroxidase.

The Journal of biological chemistry - 10 Sept 2004

Bertrand Thomas, Eady Nigel A J, Jones Jamie N, Jesmin, Nagy Judit M, Jamart-Grégoire Brigitte, Raven Emma Lloyd, Brown Katherine A

Abstract excerpt

The Mycobacterium tuberculosis catalase-peroxidase is a multifunctional heme-dependent enzyme that activates the core anti-tuberculosis drug isoniazid. Numerous studies have been undertaken to elucidate the enzyme-dependent mechanism of isoniazid activation, and it is well documented that mutations that reduce activity or inactivate the catalase-peroxidase lead to increased levels of isoniazid resistance in M....

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PMID: 15231843
DOI: 10.1074/jbc.M402382200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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