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Article

Differential HIV-1 endocytosis and susceptibility to virus infection in human macrophages correlate with cell activation status.

Journal of virology - 1 Oct 2012

Gobeil Lise-Andrée, Lodge Robert, Tremblay Michel J

Abstract excerpt

HIV-1 is an enveloped virus that enters target cells by fusion either directly at the plasma membrane or at the endosomal membrane. The latter mechanism follows a rapid engulfment of HIV-1 after its receptor engagement at the cell surface, and its scale depends on cellular endocytosis/degradation rates and virus fusion kinetics. HIV-1 has recently been shown to exploit a novel Pak1-dependent macropinocytosis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22787228
DOI: 10.1128/JVI.01051-12
PMCID: PMC3457310

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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