Article
PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites.
Hypertension (Dallas, Tex. : 1979) - 1 Apr 2005
Andersen Gitte, Wegner Lise, Jensen Dorit Packert, Glümer Charlotte, Tarnow Lise, Drivsholm Thomas, Poulsen Pernille, Hansen Sara Kristine, Nielsen Eva-Maria Damsgaard, Ek Jakob, Mouritzen Peter, Vaag Allan, Parving Hans-Henrik, Borch-Johnsen Knut, Jørgensen Torben, Hansen Torben, Pedersen Oluf
Abstract excerpt
PGC-1alpha is a coactivator of numerous transcription factors and is expressed in tissues with high energy demands and abundant in mitochondria. It is induced in the myocardium on fasting and physical exercise, and cardiac-specific overexpression stimulates mitochondrial biogenesis in mice. The common Gly482Ser polymorphism of PGC-1alpha has previously shown association with arterial hypertension among Austrian...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.