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Article

Overexpression of Smad2 in Tgf-beta3-null mutant mice rescues cleft palate.

Developmental biology - 1 Feb 2005

Cui Xiao-Mei, Shiomi Nobuyuki, Chen Jucheng, Saito Takashi, Yamamoto Tadashi, Ito Yoshihiro, Bringas Pablo, Chai Yang, Shuler Charles F

Abstract excerpt

Transforming growth factor (TGF)-beta3 is an important contributor to the regulation of medial edge epithelium (MEE) disappearance during palatal fusion. SMAD2 phosphorylation in the MEE has been shown to be directly regulated by TGF-beta3. No phospho-SMAD2 was identified in the MEE in Tgf-beta3-null mutant mice (Tgf-beta3-/-), which was correlated with the persistence of the MEE and failure of palatal fusion. In...

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Source

Identifiers

PMID: 15649471
DOI: 10.1016/j.ydbio.2004.10.023

Genes

SMAD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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