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Article

p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate.

PLoS genetics - 1 Jun 2017

Richardson Rose, Mitchell Karen, Hammond Nigel L, Mollo Maria Rosaria, Kouwenhoven Evelyn N, Wyatt Niki D, Donaldson Ian J, Zeef Leo, Burgis Tim, Blance Rognvald, van Heeringen Simon J, Stunnenberg Hendrik G, Zhou Huiqing, Missero Caterina, Romano Rose Anne, Sinha Satrajit, Dixon Michael J, Dixon Jill

Abstract excerpt

Cleft palate is a common congenital disorder that affects up to 1 in 2500 live births and results in considerable morbidity to affected individuals and their families. The aetiology of cleft palate is complex with both genetic and environmental factors implicated. Mutations in the transcription factor p63 are one of the major individual causes of cleft palate; however, the gene regulatory networks in which p63...

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Identifiers

PMID: 28604778
DOI: 10.1371/journal.pgen.1006828
PMCID: PMC5484519

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Source receipt: pubmed, retrieved 7 Sept 2026.

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