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Article

Tak1, Smad4 and Trim33 redundantly mediate TGF-β3 signaling during palate development.

Developmental biology - 15 Feb 2015

Lane Jamie, Yumoto Kenji, Azhar Mohamad, Ninomiya-Tsuji Jun, Inagaki Maiko, Hu Yingling, Deng Chu-Xia, Kim Jieun, Mishina Yuji, Kaartinen Vesa

Abstract excerpt

Transforming growth factor-beta3 (TGF-β3) plays a critical role in palatal epithelial cells by inducing palatal epithelial fusion, failure of which results in cleft palate, one of the most common birth defects in humans. Recent studies have shown that Smad-dependent and Smad-independent pathways work redundantly to transduce TGF-β3 signaling in palatal epithelial cells. However, detailed mechanisms by which this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25523394
DOI: 10.1016/j.ydbio.2014.12.006
PMCID: PMC4314443

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