CD14 and TLR4 gene polymorphisms in adult periodontitis.

doi:10.1177/154405910508401114

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

CD14 and TLR4 gene polymorphisms in adult periodontitis.

Journal of dental research - 1 Nov 2005

Laine M L, Morré S A, Murillo L S, van Winkelhoff A-J, Peña A S

Abstract excerpt

Bacterial deposits, smoking, and host genetic factors play a major role in an individual's predisposition to periodontitis. Bacterial components are recognized by CD14 and toll-like receptor 4 (TLR4), resulting in a NF-kappaB-based inflammatory response. We hypothesized that functional CD14 and TLR4 polymorphisms contribute to periodontitis susceptibility. We aimed to investigate the occurrence of CD14-260C>T,...

Topics

Adult
Age Factors
Aged
Aggregatibacter actinomycetemcomitans
Aspartic Acid
Cytosine
Disease Susceptibility
Female
Genetic Predisposition to Disease
Glycine
Humans
Isoleucine
Lipopolysaccharide Receptors
Male
Middle Aged
Periodontitis
Polymorphism, Genetic
Porphyromonas gingivalis

Source

Open in PubMed

Identifiers

PMID: 16246938
DOI: 10.1177/154405910508401114

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics