Article
mtDNA mutations increase tumorigenicity in prostate cancer.
Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 2005
Petros John A, Baumann Amanda K, Ruiz-Pesini Eduardo, Amin Mahul B, Sun Carrie Qi, Hall John, Lim SoDug, Issa Muta M, Flanders W Dana, Hosseini Seyed H, Marshall Fray F, Wallace Douglas C
Abstract excerpt
Mutations in the mtDNA have been found to fulfill all of the criteria expected for pathogenic mutations causing prostate cancer. Focusing on the cytochrome oxidase subunit I (COI) gene, we found that 11-12% of all prostate cancer patients harbored COI mutations that altered conserved amino acids (mean conservation index=83%), whereas <2% of no-cancer controls and 7.8% of the general population had COI mutations,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.