Article
Stable expression of constitutively-activated STAT3 in benign prostatic epithelial cells changes their phenotype to that resembling malignant cells.
Molecular cancer - 12 Jan 2005
Huang Hosea F, Murphy Thomas F, Shu Ping, Barton Arnold B, Barton Beverly E
Abstract excerpt
BACKGROUND: Signal transducers and activators of transcription (STATs) are involved in growth regulation of cells. They are usually activated by phosphorylation at specific tyrosine residues. In neoplastic cells, constitutive activation of STATs accompanies growth dysregulation and resistance to apoptosis through changes in gene expression, such as enhanced anti-apoptotic gene expression or reduced pro-apoptotic...
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