Article
PC-3 cells with enhanced androgen receptor signaling: a model for clonal selection in prostate cancer.
The Prostate - 1 Sept 2004
Buchanan Grant, Craft Paul S, Yang Miao, Cheong Albert, Prescott Jennifer, Jia Li, Coetzee Gerhard A, Tilley Wayne D
Abstract excerpt
BACKGROUND: Two sublines of the human prostate cancer cell line, PC-3, which is widely used as a model of prostate cancer progression, have been reported: PC-3(AR-) that do not express androgen receptor (AR), and PC-3AR+ that have measurable AR RNA but little protein. METHODS: We assayed the geneotype, karyotype, AR expression, and physical characteristics of the two PC-3 sublines, and compared their ability to...
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