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Article

Androgen-induced proliferative quiescence in prostate cancer cells: The role of AS3 as its mediator

29 Aug 2000

Abstract excerpt

In the prostate gland of adult mammals, most epithelial cells are in a state of proliferative quiescence. Androgens regulate this effect by inducing cell cycle arrest in the G(0)/G(1) phase. Potential mediators of this androgen-induced proliferative shutoff were identified by means of subtracted cDNA libraries. The expression pattern of one of these sequences, AS3, strongly correlated with the expression of the...

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PMID: 10963680
DOI: 10.1073/pnas.97.18.10185

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