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Article

STAT3 mediates IL-6-induced growth inhibition in the human prostate cancer cell line LNCaP.

The Prostate - 1 Feb 2000

Spiotto M T, Chung T D

Abstract excerpt

BACKGROUND: In prostate cancer, we and others have observed distinct phenotypic responses to interleukin-6 (IL-6), which acts either as a paracrine growth inhibitor in the LNCaP cell line or as an autocrine growth stimulator in PC-3, DU145, and TSU cell lines. To understand the underlying mechani...

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Source

Identifiers

PMID: 10617865
DOI: 10.1002/(sici)1097-0045(20000201)42:2<88::aid-pros2>3.0.co;2-p

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10617865-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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STAT3 mediates IL-6-induced growth inhibition in the human prostate cancer cell line LNCaP.PMID 10617865Read ↗

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STAT3 mediates IL-6-induced neuroendocrine differentiation in prostate cancer cellsSemantic proximity Read ↗

Interleukin-6 promotes androgen-independent growth in LNCaP human prostate cancer cells.Semantic proximity Read ↗

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Cell-autonomous IL6ST activation suppresses prostate cancer development via STAT3/ARF/p53-driven senescence and confers an immune-active tumor microenvironmentSemantic proximity Read ↗

Impact of STAT Proteins in Tumor Progress and Therapy Resistance in Advanced and Metastasized Prostate CancerSemantic proximity Read ↗

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IL-6 signaling by STAT3 participates in the change from hyperplasia to neoplasia in NRP-152 and NRP-154 rat prostatic epithelial cells.Semantic proximity Read ↗

Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling.Semantic proximity Read ↗

Early Growth Response 3 regulates genes of inflammation and directly activates IL6 and IL8 expression in prostate cancerSemantic proximity Read ↗

Establishment of a highly tumorigenic LNCaP cell line having inflammatory cytokine resistance.Semantic proximity Read ↗

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