Article
A genome-wide screen on the genetics of atopy in a multiethnic European population reveals a major atopy locus on chromosome 3q21.3.
Allergy - 1 Feb 2005
Kurz T, Altmueller J, Strauch K, Rüschendorf F, Heinzmann A, Moffatt M F, Cookson W O C M, Inacio F, Nürnberg P, Stassen H H, Deichmann K A
Abstract excerpt
BACKGROUND: Dissecting complex diseases in underlying distinct traits and studying these for their genetic basis might enhance the power as well as the specificity, of detection of disease genes. These phenotypes are known as intermediate phenotypes. OBJECTIVE: We were interested in the atopic basis of asthma, and used the sensitization to mite (Dermatophagoides pteronyssinus) allergens as a pathophysiologically...
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