Article
The clinical presentation of autoimmune thyroid disease in men is associated with IL12B genotype.
Clinical endocrinology - 1 Apr 2011
Walsh John P, Berry Jemma, Liu Shu, Panicker Vijay, Dayan Colin M, Brix Thomas H, Hegedüs Laszlo, Hou Peng, Shi Bingyin, Morahan Grant
Abstract excerpt
BACKGROUND: Common variants in the interleukin 12B (IL12B) gene are associated with predominantly inflammatory (Th1) or antibody-mediated (Th2) immune responses. As Hashimoto's disease and Graves' disease are thought to arise from mainly Th1 and Th2 immune responses respectively, we hypothesized...
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