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Article

Vitamin D receptor and Alzheimer's disease: a genetic and functional study.

Neurobiology of aging - 1 Aug 2012

Wang Liyong, Hara Kenju, Van Baaren Jessica M, Price Justin C, Beecham Gary W, Gallins Paul J, Whitehead Patrice L, Wang Gaofeng, Lu Chunrong, Slifer Michael A, Züchner Stephan, Martin Eden R, Mash Deborah, Haines Jonathan L, Pericak-Vance Margaret A, Gilbert John R

Abstract excerpt

Genetic studies on late-onset Alzheimer's disease (AD) have repeatedly mapped susceptibility loci onto chromosome 12q13, encompassing the vitamin D receptor (VDR) gene. Epidemiology studies have indicated vitamin D insufficiency as a risk factor for AD. Given that VDR is the major mediator for vitamin D's actions, we sought to clarify the role of VDR in late-onset AD. We conducted an association study in 492...

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Source

Identifiers

PMID: 22306846
DOI: 10.1016/j.neurobiolaging.2011.12.038

Genes

VDR
APP
CDX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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