Article
Genetic analysis of SLC11A1 polymorphisms in multiple sclerosis patients.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Dec 2004
Comabella Manuel, Altet Laura, Peris Francesc, Villoslada Pablo, Sánchez Armand, Montalban Xavier
Abstract excerpt
Solute carrier 11a1 (SLC11A1; formerly NRAMP1, where NRAMP stands for natural resistance-associated macrophage protein) is a proton/bivalent cation antiporter that localizes to late endosomes/lysosomes. SLC11A1 regulates macrophage functions that are of potential importance in the induction and/or maintenance of autoimmune diseases such as rheumatoid arthritis, type I diabetes and Crohn's disease. We investigated...
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