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Article

Mutagenesis-based evidence for an asymmetric configuration of the ring-shaped transcription termination factor Rho.

Journal of molecular biology - 14 Jan 2011

Rabhi Makhlouf, Gocheva Veronika, Jacquinot Frédérique, Lee Andrea, Margeat Emmanuel, Boudvillain Marc

Abstract excerpt

Transcription termination factor Rho is an ATP-dependent ring-shaped molecular motor that tracks along RNA to dissociate RNA-DNA duplexes and transcription complexes in its path. The Rho hexamer contains two distinct sites for interaction with RNA. The primary binding site is composed of pyrimidine-specific binding clefts that are located in the N-terminal domains and anchor Rho to transcripts at C-rich Rut (Rho...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 21059356
DOI: 10.1016/j.jmb.2010.11.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutagenesis-based evidence for an asymmetric configuration of the ring-shaped transcription termination factor Rho.PMID 21059356Read ↗

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Transcription termination defective mutants of Rho: role of different functions of Rho in releasing RNA from the elongation complex.Semantic proximity Read ↗

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An allosteric mechanism of Rho-dependent transcription termination.Semantic proximity Read ↗

Mutations in an RNP1 consensus sequence of Rho protein reduce RNA binding affinity but facilitate helicase turnover.Semantic proximity Read ↗

Mutations in the ATP-binding domain of Escherichia coli rho factor affect transcription termination in vivo.Semantic proximity Read ↗

Redundancy of primary RNA-binding functions of the bacterial transcription terminator Rho.Semantic proximity Read ↗

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ATP binding to Rho transcription termination factor. Mutant F355W ATP-induced fluorescence quenching reveals dynamic ATP binding.Semantic proximity Read ↗

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Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic bicyclomycin.Semantic proximity Read ↗

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