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Article

Mutation of regulatory serines of rat tyrosine hydroxylase to glutamate: effects on enzyme stability and activity.

Archives of biochemistry and biophysics - 15 Feb 2005

Royo Montserrat, Fitzpatrick Paul F, Daubner S Colette

Abstract excerpt

Tyrosine hydroxylase is phosphorylated at four serine residues in its amino-terminus by multiple kinases. Phosphorylation of serine 40 by cAMP-dependent protein kinase results in alleviation of dopamine inhibition [J. Biol. Chem. 267 (1992) 12639]. The other serines are at positions 8, 19, and 31. The effect of phosphorylation at these serines has been investigated using mutated forms of tyrosine hydroxylase...

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Identifiers

PMID: 15639226
DOI: 10.1016/j.abb.2004.11.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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