Article
Serines at the active site of 11 beta-hydroxysteroid dehydrogenase type I determine the rate of catalysis.
Biochemical and biophysical research communications - 18 Sept 1998
Obeyesekere V R, Trzeciak W H, Li K X, Krozowski Z S
Abstract excerpt
Short chain alcohol dehydrogenases have an invariant YXXXK motif at the active site. Database analysis of 116 superfamily members showed that 92% also contain a Serine or Threonine residue at the Y + 1 or Y + 3 positions, a pattern we previously described as the ST rule. In the present study we have mutated Serines in the active site, YSASK, motif of 11 beta-hydroxysteroid dehydrogenase type I (11 beta HSD1)....
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