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Article

Roles of conserved amino acid sequence motifs in the SpoU (TrmH) RNA methyltransferase family.

The Journal of biological chemistry - 18 Mar 2005

Watanabe Kazunori, Nureki Osamu, Fukai Shuya, Ishii Ryohei, Okamoto Hironori, Yokoyama Shigeyuki, Endo Yaeta, Hori Hiroyuki

Abstract excerpt

Transfer RNA (Gm18) methyltransferase (TrmH (SpoU)) catalyzes the transfer of a methyl group from S-adenosyl-l-methionine (AdoMet) to the 2'-OH of guanosine 18 in tRNA. This enzyme is a member of the SpoU family of RNA methyltransferases. Recent computational researches have shown that three amino acid sequence motifs are conserved among the SpoU members. Recently, we determined the crystal structures of the...

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PMID: 15637073
DOI: 10.1074/jbc.M411209200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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